ESPID 2001, Istanbul
The Effect of Varicella Vaccination in Asthmatic Children Receiving Inhaled Steroids
Emine Kocabas, Gulbin Bingol Karakoc, Derya Alabaz, Mustafa Yilmaz, Derya Altintas, Necmi Aksaray
Cukurova University, Faculty of Medicine, Department of Pediatric Infectious Diseases, Adana, Turkey
Neither nasal nor oral inhalation of corticosteroids predisposes patients to systemic infectious diseases including severe varicella infection. The purpose of this study is to investigate the efficacy of varicella vaccine in asthmatic children receiving inhaled steroids. Seventeen children with mild persistent or moderate asthma receiving inhaled steroids (100-400mg/day) with no history of varicella infection were included in this study. Of the study group 10 were boys and 7 were girls with the mean age of 5.7 + 2.8 years (range: 3 - 13 years). All patients were vaccinated with a single dose varicella vaccine. Serum Ig antibodies against varicella virus were measured by ELISA (Human Biochemica und Diagnostica, Germany) at baseline and at 4 weeks after vaccination. The control group was constituted by 20 age and sex-matched asthmatic children of no history of varicella infection, unvaccinated, and seronegative for varicella. The study and the control groups were followed for varicella infection for one year. Seroconversion 4 weeks after vaccination was detected in 13 of 17 varicella-seronegative children (76.4%). No varicella infection was observed in the follow-up period. Three children had varicella infection in the unvaccinated group (15%) and annual infection risk was 3 %. In conclusion, our results suggest that varicella vaccine has a high protective rate in asthmatic children receiving inhaled steroids.
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